Last edited by Bazilkree
Sunday, November 8, 2020 | History

3 edition of Channelopathies (Advances in Molecular and Cell Biology) found in the catalog.

Channelopathies (Advances in Molecular and Cell Biology)

Frank Lehmann Horn

Channelopathies (Advances in Molecular and Cell Biology)

  • 116 Want to read
  • 4 Currently reading

Published by Jai Pr .
Written in English

    Subjects:
  • Cellular biology,
  • Mathematics and Science,
  • Molecular biology,
  • Life Sciences - Biology - Molecular Biology,
  • Life Sciences - Cytology,
  • Science,
  • Science/Mathematics

  • The Physical Object
    FormatHardcover
    ID Numbers
    Open LibraryOL10908700M
    ISBN 100762306238
    ISBN 109780762306237
    OCLC/WorldCa228296796

    This chapter focuses on the periodic paralyses and the nondystrophic myotonias. The periodic paralyses are rare, dominantly inherited disorders characterized by the onset of episodic weakness, usually in childhood or adolescence, often with alteration of potassium level. Patients initially recover strength between attacks, but if attacks are not treated, progressive weakness develops. Ion channels and disease: channelopathies. [Frances M Ashcroft] -- Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. This book is intended for research workers and clinicians, as well as graduates and advanced. Channelopathy constitutes significant proportion of SCD worldwide (around 10% or , deaths annually). It was creating a mysterious group of diseases until the second half of the last century when Anton Jervell and Fred Lange-Nielsen described Jervell Lange-Nielsen syndrome in It was late until where genetic characterization commenced. Later on, the massive genetic information. Channelopathies in Heart Disease. Editors: Thomas, Dierk, Remme, Carol Ann (Eds.) Free Preview. Unique work on channelopathies in cardiac disease, describing cellular mechanisms, scientific methodologies as well as clinical relevance The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of.


Share this book
You might also like
Scot in history

Scot in history

Universities, ethics, and professions

Universities, ethics, and professions

The American Catholic quarterly review

The American Catholic quarterly review

Record of the descendants of George Hubbard, one of founders of Wethersfield, Milford, and Guilford, Connecticut

Record of the descendants of George Hubbard, one of founders of Wethersfield, Milford, and Guilford, Connecticut

2007 virtual rehabilitation

2007 virtual rehabilitation

North American Indians : A Comprehensive Account -- 2nd ed.

North American Indians : A Comprehensive Account -- 2nd ed.

Information technology awareness in engineering

Information technology awareness in engineering

Mill residues in 3 Oregon counties

Mill residues in 3 Oregon counties

Tests of Additives to Control Soot Deposition in Oil-Fired Boilers.

Tests of Additives to Control Soot Deposition in Oil-Fired Boilers.

Birds (Golden Guides)

Birds (Golden Guides)

School management

School management

seriousness of money laundering in Malawi

seriousness of money laundering in Malawi

Arubas people, progress and potential

Arubas people, progress and potential

The whole book of Psalms, in metre

The whole book of Psalms, in metre

KONOSHIMA CHEMICAL CO., LTD.

KONOSHIMA CHEMICAL CO., LTD.

Channelopathies (Advances in Molecular and Cell Biology) by Frank Lehmann Horn Download PDF EPUB FB2

Richard Bertram, Richard L. Hyson, in Reference Channelopathies book in Biomedical Sciences, Channelopathies. Channelopathies are diseases related to dysfunctions of ion channels (Kullmann and Waxman, ).These can be congenital, typically due to a genetic mutation in an ion channel gene, or acquired, such as due to an autoimmune attack on a specific type of ion channel.

This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a.

Table of Contents * A unique reference focusing on the rapidly developing field of channelopathies of common neurological disorders * Written specifically for the clinical neurologist and neuroscientist * It reviews the underlying scientific principles of ion channel function and the current research and its clinical applicationsPages: Ion Channels and Disease: Channelopathies (Quantitative Finance) eBook: Ashcroft, Frances M.: : Kindle Store/5(3).

A unique reference focusing on the rapidly developing field of channelopathies of common neurological disorders Written specifically for the clinical neurologist and neuroscientist It. channelopathy A popular term for a heterogeneous group of conditions caused by structural (due to mutations) or functional (acquired, e.g., autoimmune) defects in ion channels or their regulatory proteins.

Examples Cystic fibrosis, Dent’s disease, long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia, Brugada. Cardiac channelopathies are an emerging set of congenital or acquired genetic disorders manifesting with disruption of cardiac ion channel function leading to altered electrical function and predisposition to dysrhythmia and sudden death.

From: Cardiovascular Pathology (Fourth Edition), Related terms: Brugada Syndrome. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications.

Muscle Channelopathies. Muscle channelopathies are a group of nondystrophic myopathies which are caused by mutations that result in malfunction of the muscle ionic channels.

Depending on the type of the channel involved, they may manifest with myotonia, paramyotonia, periodic paralysis, or MH [,].

The symptoms of channelopathies can vary widely depending on what part of the body is affected. In the nervous system, it might result in muscle paralysis, muscle twitching or muscle stiffness.

People with channelopathies that affect the heart can experience seizures, an abnormal heart rhythm and other symptoms. This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a Channelopathies book and interdisciplinary readership.

Genetics. BrS is a channelopathy with an autosomal-dominant pattern of inheritance. The first genetic alteration associated with BrS was identified in the SCN5A gene encoding the α-subunit of the cardiac sodium channel, Nav [].Since then, more than pathogenic variants have been identified in 24 genes encoding sodium, potassium, and calcium channels or associated proteins.

Congenital long QT syndrome (LQTS) comprises a distinct group of cardiac channelopathies characterized by delayed repolarization of the myocardium, QT prolongation and increased risk of syncope, seizures and sudden cardiac death in the Channelopathies book of a structurally normal heart and otherwise healthy person (Figure 1).

This repolarization abnormality usually is without consequence. This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary : $ Ion channelopathies are a group of rare something to keep you occupied, like a book or tablet to watch TV on as there will be time between tests and meetings.

We have a limited amount of toys, so please bring some fun things to do for any children attending the clinic. Channelopathy definition is - any of various disorders (such as epilepsy, migraine, cystic fibrosis, heart arrhythmia, and myotonia) caused by the malfunction of an ion channel.

How to use channelopathy in a sentence. Channelopathies. Channelopathies are a group of cardiac conditions that display defects in ion channel and transporter function. Most conditions are due to inherited mutations that disrupt ion channel biophysical properties.

However, other defects arise from disruptions in ion channel membrane trafficking and post-translational modifications []. The field of channelopathies is expanding rapidly, as is the utility of molecular-genetic and electrophysiological studies.

This review provides a brief overview and update of channelopathies. Home Books Hurst's The Heart, 14e. The term cardiac channelopathies refers to a group of genetic diseases in which the primary dysfunction is an abnormal electrophysiologic substrate creating susceptibility to arrhythmias in the context of a substantially normal cardiac structure.

Neurological channelopathies in a snapshot. Although the term ‘channelopathy’ was coined less than 20 years ago, inherited mutations of ion channels are now recognised to affect a wide range of organs and to represent a substantial disease burden.

An increasing number of neurological channelopathies have been identified and. neurological channelopathies are subdivided on the basis of channel type. Table 2 is a list of genetic neurological channelopathies according to ion type.

Most ion channels have a similar basic structure. All voltage gated ion channels have a large pore forming subunit. Skeletal myopathies caused by channelopathies 7. Endocrine disorders caused by channelopathies 8. Emerging roles of CaCC channels in health and disease 9. New roles for ion channels in neuropsychiatric disorders Pharmacology and pathophysiology of calcium channels Inherited cardiac arrhythmias Ion channels and diabetes   This book reviews a wide variety of congenital and acquired conditions caused by abnormalities in ion-transport mechanisms.

It starts with a description of relatively simple channels that respond to voltage changes or certain cellular metabolites by a Reviews: 5. Find helpful customer reviews and review ratings for Ion Channels and Disease: Channelopathies (Quantitative Finance) at Read honest and unbiased product reviews from our users.

Neurological channelopathies in a snapshot. Although the term ‘channelopathy’ was coined less than 20 years ago, inherited mutations of ion channels are now recognised to affect a wide range of organs and to represent a substantial disease burden.

The “Hot Topic Keynotes: Channelopathies” session of the 26thInternational Neurotoxicology Conference brought together toxicologists studying interactions of environmental toxicants with ion channels, to review the state of the science of channelopathies and to discuss the potential for interactions between environmental exposures and channelopathies.

Chapter 8 of the book – Channelopathies. Ion channels are specialised transmembrane proteins that are essential for controlling electrical signalling and neurotransmitter release throughout the nervous system. When comorbid neurological or behavioural disorders affect an individual, the explanation may be found in a single ion channel.

A channelopathy is the result of a mutation(s) in the gene encoding the channel, producing changes in channel properties sufficient to produce clinical symptoms. These changes are generally. Often overlooked are channelopathies such as the short 3, 4 or long QT and Brugada syndromes, in which mutations in the gene (SCN5A) encoding the alpha subunit of the cardiac sodium channel (NaV) are known to be involved.

5 Brugada syndrome is an inherited cardiac disorder predisposing to ventricular arrhythmias 6 with characteristic ECG. Inherited arrhythmias are defined; genetic mechanisms of channelopathies are presented, and a glossary on the terms used in genetics is provided.

Public users are able to search the site and view the abstracts for each book and chapter without a subscription. Please subscribe or. This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease.

Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field.

Get this from a library. Channelopathies: common mechanisms in aura, arrhythmia, and alkalosis. [Karin Jurkat-Rott; Frank Lehmann-Horn;] -- This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a.

The first book with a comprehensive overview of channelopathies appeared in The channelopathies affecting skeletal muscle excitability have been reviewed in the clinical literature (, ) as well as in mechanistic reviews on the physiology of.

eBook is an electronic version of a traditional print book THIS can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THIS is used solely as a reading device such as Nuvomedia's Rocket eBook.).

Channelopathies are diseases caused by disturbed function of ion channel subunits or the proteins that regulate them. These diseases may be either congenital (often resulting from a mutation or mutations in the encoding genes) or acquired (often resulting from autoimmune attack on an ion channel).

There are many distinct dysfunctions known to be caused by ion channel mutations. Evidence accumulated over recent years has shown that genetic neurological channelopathies can cause many different neurological diseases. Presentations relating to the brain, spinal cord, peripheral nerve or muscle mean that channelopathies can impact on almost any area of neurological practice.

Evidence accumulated over recent years has shown that genetic neurological channelopathies can cause many different neurological diseases. Presentations relating to the brain, spinal cord, peripheral nerve or muscle mean that channelopathies can impact on almost any area of neurological practice.

Typically, neurological channelopathies are inherited in an autosomal dominant fashion and cause. "This book provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies.

An increased understanding of the pathophysiological mechanisms, better anti-arrhythmic strategies, and, in particular, more epidemiological data on exercise-induced arrhythmia in active athletes with channelopathies have changed the universal recommendation [].

Epidemiology of migraine and headache in children and adolescents. Curr Pain Headache Rep. Jun. 17 (6). Channelopathies are disorders in which absence of ion channels, abnormal function of ion channels, or deployment of an aberrant of ensemble of ion channels produce clinical symptoms.

Migraine.Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function.

Most of these diseases arise from mutations in the genes encoding ion channel proteins, and.“Channelopathies” refer to a class of diseases caused by ion‐channel dysfunction. Autoimmune, drug, toxic or genetic mechanisms underlie channelopathies.

Mutations in genes encoding ion‐channel proteins that alter channel function are common mechanisms underlying the cause of channelopathies.